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It took six months, but Hillary Clinton is finally giving her first major address as Secretary of State on Wednesday. Politico reports that Clinton, in a speech at the Council on Foreign Relations, will promise that the U.S. will "remain clear-eyed about our purpose," and warn opponents that they "should never see America's willingness to talk as a sign of weakness to be exploited." She also sets out the administration's foreign-policy priorities, which include preventing nuclear proliferation; isolating terrorists and reaching out to Muslims; facilitating peace in the Middle East; pursuing global economic recovery; combating climate change; and defending human rights.